The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection—suramin inhibits EV71 infection in vitro and in vivo
Identifieur interne : 003451 ( Main/Exploration ); précédent : 003450; suivant : 003452The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection—suramin inhibits EV71 infection in vitro and in vivo
Auteurs : Peijun Ren [République populaire de Chine, France] ; Gang Zou [République populaire de Chine] ; Benjamin Bailly [République populaire de Chine, Australie] ; Shanshan Xu [République populaire de Chine] ; Mei Zeng [République populaire de Chine] ; Xinsheng Chen [République populaire de Chine] ; Liang Shen [République populaire de Chine] ; Ying Zhang [République populaire de Chine] ; Patrice Guillon [Australie] ; Fernando Arenzana-Seisdedos [France] ; Philippe Buchy [Cambodge] ; Jian Li [République populaire de Chine] ; Mark Von Itzstein [Australie] ; Qihan Li [République populaire de Chine] ; Ralf Altmeyer [République populaire de Chine]Source :
- Emerging Microbes & Infections [ 2222-1751 ] ; 2014.
Abstract
Enterovirus 71 (EV71) causes severe central nervous system infections, leading to cardiopulmonary complications and death in young children. There is an urgent unmet medical need for new pharmaceutical agents to control EV71 infections. Using a multidisciplinary approach, we found that the approved pediatric antiparasitic drug suramin blocked EV71 infectivity by a novel mechanism of action that involves binding of the naphtalentrisulonic acid group of suramin to the viral capsid. Moreover, we demonstrate that when suramin is used
Url:
DOI: 10.1038/emi.2014.60
PubMed: 26038755
PubMed Central: 4185360
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection—suramin inhibits EV71 infection <italic>in vitro</italic> and <italic>in vivo</italic></title><author><name sortKey="Ren, Peijun" sort="Ren, Peijun" uniqKey="Ren P" first="Peijun" last="Ren">Peijun Ren</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Unit of Anti-infective Research, Institut Pasteur of Shanghai</institution>, Chinese Academy of Sciences, Shanghai 200031,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Université Paris Diderot, Sorbonne Paris Cité, Cellule Pasteur</institution>, 75013, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Institut National de la Santé et de la Recherche Médicale, U1108 & Viral Pathogenesis Unit, Department of Virology, Institut Pasteur</institution>, 75724 Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zou, Gang" sort="Zou, Gang" uniqKey="Zou G" first="Gang" last="Zou">Gang Zou</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Unit of Anti-infective Research, Institut Pasteur of Shanghai</institution>, Chinese Academy of Sciences, Shanghai 200031,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bailly, Benjamin" sort="Bailly, Benjamin" uniqKey="Bailly B" 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xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Buchy, Philippe" sort="Buchy, Philippe" uniqKey="Buchy P" first="Philippe" last="Buchy">Philippe Buchy</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Virology Unit, Institut Pasteur in Cambodia</institution>, 12201 Phnom Penh,<country>Cambodia</country></nlm:aff><country xml:lang="fr">Cambodge</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Jian" sort="Li, Jian" uniqKey="Li J" first="Jian" last="Li">Jian Li</name><affiliation wicri:level="1"><nlm:aff id="aff6">State Key Laboratory of Lead Compound Research, WuXi AppTec, Co., Ltd, Shanghai 200131,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Von 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type="wicri:Area/Main/Exploration">003451</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection—suramin inhibits EV71 infection <italic>in vitro</italic> and <italic>in vivo</italic></title><author><name sortKey="Ren, Peijun" sort="Ren, Peijun" uniqKey="Ren P" first="Peijun" last="Ren">Peijun Ren</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Unit of Anti-infective Research, Institut Pasteur of Shanghai</institution>, Chinese Academy of Sciences, Shanghai 200031,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Université Paris Diderot, Sorbonne Paris Cité, Cellule Pasteur</institution>, 75013, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Institut National de la Santé et de la Recherche Médicale, U1108 & Viral Pathogenesis Unit, Department of Virology, Institut Pasteur</institution>, 75724 Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zou, Gang" sort="Zou, Gang" uniqKey="Zou G" first="Gang" last="Zou">Gang Zou</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Unit of Anti-infective Research, Institut Pasteur of Shanghai</institution>, Chinese Academy of Sciences, Shanghai 200031,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bailly, Benjamin" sort="Bailly, Benjamin" uniqKey="Bailly B" first="Benjamin" last="Bailly">Benjamin Bailly</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Unit of Anti-infective Research, Institut Pasteur of Shanghai</institution>, Chinese Academy of Sciences, Shanghai 200031,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Institute for Glycomics, Gold Coast Campus, Griffith University</institution>, 4222 Queensland,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Shanshan" sort="Xu, Shanshan" uniqKey="Xu S" first="Shanshan" last="Xu">Shanshan Xu</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Unit of Anti-infective Research, Institut Pasteur of Shanghai</institution>, Chinese Academy of Sciences, Shanghai 200031,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zeng, Mei" sort="Zeng, Mei" uniqKey="Zeng M" first="Mei" last="Zeng">Mei Zeng</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Department of Infectious Diseases, Children's Hospital of Fudan University</institution>, Shanghai 201102,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Xinsheng" sort="Chen, Xinsheng" uniqKey="Chen X" first="Xinsheng" last="Chen">Xinsheng Chen</name><affiliation wicri:level="1"><nlm:aff id="aff6">State Key Laboratory of Lead Compound Research, WuXi AppTec, Co., Ltd, Shanghai 200131,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shen, Liang" sort="Shen, Liang" uniqKey="Shen L" first="Liang" last="Shen">Liang Shen</name><affiliation wicri:level="1"><nlm:aff id="aff6">State Key Laboratory of Lead Compound Research, WuXi AppTec, Co., Ltd, Shanghai 200131,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Ying" sort="Zhang, Ying" uniqKey="Zhang Y" first="Ying" last="Zhang">Ying Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Institute of Medical Biology, Chinese Academy of Medicine Science</institution>, Kunming 650118, Yunnan Province,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guillon, Patrice" sort="Guillon, Patrice" uniqKey="Guillon P" first="Patrice" last="Guillon">Patrice Guillon</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Institute for Glycomics, Gold Coast Campus, Griffith University</institution>, 4222 Queensland,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Arenzana Seisdedos, Fernando" sort="Arenzana Seisdedos, Fernando" uniqKey="Arenzana Seisdedos F" first="Fernando" last="Arenzana-Seisdedos">Fernando Arenzana-Seisdedos</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Institut National de la Santé et de la Recherche Médicale, U1108 & Viral Pathogenesis Unit, Department of Virology, Institut Pasteur</institution>, 75724 Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Buchy, Philippe" sort="Buchy, Philippe" uniqKey="Buchy P" first="Philippe" last="Buchy">Philippe Buchy</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Virology Unit, Institut Pasteur in Cambodia</institution>, 12201 Phnom Penh,<country>Cambodia</country></nlm:aff><country xml:lang="fr">Cambodge</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Jian" sort="Li, Jian" uniqKey="Li J" first="Jian" last="Li">Jian Li</name><affiliation wicri:level="1"><nlm:aff id="aff6">State Key Laboratory of Lead Compound Research, WuXi AppTec, Co., Ltd, Shanghai 200131,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Von Itzstein, Mark" sort="Von Itzstein, Mark" uniqKey="Von Itzstein M" first="Mark" last="Von Itzstein">Mark Von Itzstein</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Institute for Glycomics, Gold Coast Campus, Griffith University</institution>, 4222 Queensland,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Qihan" sort="Li, Qihan" uniqKey="Li Q" first="Qihan" last="Li">Qihan Li</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Institute of Medical Biology, Chinese Academy of Medicine Science</institution>, Kunming 650118, Yunnan Province,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Altmeyer, Ralf" sort="Altmeyer, Ralf" uniqKey="Altmeyer R" first="Ralf" last="Altmeyer">Ralf Altmeyer</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Unit of Anti-infective Research, Institut Pasteur of Shanghai</institution>, Chinese Academy of Sciences, Shanghai 200031,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Emerging Microbes & Infections</title><idno type="eISSN">2222-1751</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Enterovirus 71 (EV71) causes severe central nervous system infections, leading to cardiopulmonary complications and death in young children. There is an urgent unmet medical need for new pharmaceutical agents to control EV71 infections. Using a multidisciplinary approach, we found that the approved pediatric antiparasitic drug suramin blocked EV71 infectivity by a novel mechanism of action that involves binding of the naphtalentrisulonic acid group of suramin to the viral capsid. Moreover, we demonstrate that when suramin is used <italic>in vivo</italic> at doses equivalent to or lower than the highest dose already used in humans, it significantly decreased mortality in mice challenged with a lethal dose of EV71 and peak viral load in adult rhesus monkeys. Thus, suramin inhibits EV71 infection by neutralizing virus particles prior to cell attachment. Consequently, these findings identify suramin as a clinical candidate for further development as a therapeutic or prophylactic treatment for severe EV71 infection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Solomon, T" uniqKey="Solomon T">T Solomon</name></author><author><name sortKey="Lewthwaite, P" uniqKey="Lewthwaite P">P Lewthwaite</name></author><author><name sortKey="Perera, D" uniqKey="Perera D">D Perera</name></author><author><name sortKey="Cardosa, Mj" uniqKey="Cardosa M">MJ Cardosa</name></author><author><name sortKey="Mcminn, P" uniqKey="Mcminn P">P McMinn</name></author><author><name sortKey="Ooi, Mh" uniqKey="Ooi M">MH Ooi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Sm" uniqKey="Wang S">SM Wang</name></author><author><name sortKey="Liu, Cc" uniqKey="Liu C">CC Liu</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name 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Mouton</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Cambodge</li><li>France</li><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Ren, Peijun" sort="Ren, Peijun" uniqKey="Ren P" first="Peijun" last="Ren">Peijun Ren</name></noRegion><name sortKey="Altmeyer, Ralf" sort="Altmeyer, Ralf" uniqKey="Altmeyer R" first="Ralf" last="Altmeyer">Ralf Altmeyer</name><name sortKey="Bailly, Benjamin" sort="Bailly, Benjamin" uniqKey="Bailly B" first="Benjamin" last="Bailly">Benjamin Bailly</name><name sortKey="Chen, Xinsheng" sort="Chen, Xinsheng" uniqKey="Chen X" first="Xinsheng" last="Chen">Xinsheng Chen</name><name sortKey="Li, Jian" sort="Li, Jian" uniqKey="Li J" first="Jian" last="Li">Jian Li</name><name sortKey="Li, Qihan" sort="Li, Qihan" uniqKey="Li Q" first="Qihan" last="Li">Qihan Li</name><name sortKey="Shen, Liang" sort="Shen, Liang" uniqKey="Shen L" first="Liang" last="Shen">Liang Shen</name><name sortKey="Xu, Shanshan" sort="Xu, Shanshan" uniqKey="Xu S" first="Shanshan" last="Xu">Shanshan Xu</name><name sortKey="Zeng, Mei" sort="Zeng, Mei" uniqKey="Zeng M" first="Mei" last="Zeng">Mei Zeng</name><name sortKey="Zhang, Ying" sort="Zhang, Ying" uniqKey="Zhang Y" first="Ying" last="Zhang">Ying Zhang</name><name sortKey="Zou, Gang" sort="Zou, Gang" uniqKey="Zou G" first="Gang" last="Zou">Gang Zou</name></country><country name="France"><noRegion><name sortKey="Ren, Peijun" sort="Ren, Peijun" uniqKey="Ren P" first="Peijun" last="Ren">Peijun Ren</name></noRegion><name sortKey="Arenzana Seisdedos, Fernando" sort="Arenzana Seisdedos, Fernando" uniqKey="Arenzana Seisdedos F" first="Fernando" last="Arenzana-Seisdedos">Fernando Arenzana-Seisdedos</name><name sortKey="Ren, Peijun" sort="Ren, Peijun" uniqKey="Ren P" first="Peijun" last="Ren">Peijun Ren</name></country><country name="Australie"><noRegion><name sortKey="Bailly, Benjamin" sort="Bailly, Benjamin" uniqKey="Bailly B" first="Benjamin" last="Bailly">Benjamin Bailly</name></noRegion><name sortKey="Guillon, Patrice" sort="Guillon, Patrice" uniqKey="Guillon P" first="Patrice" last="Guillon">Patrice Guillon</name><name sortKey="Von Itzstein, Mark" sort="Von Itzstein, Mark" uniqKey="Von Itzstein M" first="Mark" last="Von Itzstein">Mark Von Itzstein</name></country><country name="Cambodge"><noRegion><name sortKey="Buchy, Philippe" sort="Buchy, Philippe" uniqKey="Buchy P" first="Philippe" last="Buchy">Philippe Buchy</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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